منابع مشابه
Protein sequence alignment techniques.
The basic algorithms for alignment of two or more protein sequences are explained. Alternative methods for scoring substitutions and gaps (insertions and deletions) are described, as are global and local alignment methods. Multiple alignment techniques are explained, including methods for profile comparison. A summary is given of programs for the alignment and analysis of protein sequences, eit...
متن کاملProtein distance matrices comparison using sequence alignment techniques
In this paper we present an efficient approach for comparing protein structures based on distance matrices. In the first step, the distance matrices are calculated and normalized in order to avoid the scaling distortion. Further, versions from these matrices are saved on different scales and for each two protein structures we compare their respective equal-scaled matrices. Thus, we avoid the pr...
متن کاملProtein multiple sequence alignment.
Protein sequence alignment is the task of identifying evolutionarily or structurally related positions in a collection of amino acid sequences. Although the protein alignment problem has been studied for several decades, many recent studies have demonstrated considerable progress in improving the accuracy or scalability of multiple and pairwise alignment tools, or in expanding the scope of task...
متن کاملDistributed Protein Sequence Alignment
Given the explosive growth of biological sequence databases and the computational complexity of aligning large sequences over extremely large databases most researchers have opted for utilizing the BLAST algorithm. While BLAST is completely appropriate for some purposes, the more rigorous and more computationally expensive Smith-Waterman algorithm is preferred for certain purposes. This work pr...
متن کاملMultiple protein sequence alignment.
Multiple sequence alignments are essential in computational analysis of protein sequences and structures, with applications in structure modeling, functional site prediction, phylogenetic analysis and sequence database searching. Constructing accurate multiple alignments for divergent protein sequences remains a difficult computational task, and alignment speed becomes an issue for large sequen...
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ژورنال
عنوان ژورنال: Acta Crystallographica Section D Biological Crystallography
سال: 1998
ISSN: 0907-4449
DOI: 10.1107/s0907444998008324